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Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant

by Tsz Hei Fong et al.

This article discusses the role of the prefrontal cortex in mediating passive coping behaviors in response to chronic stress and the effects of fast-acting antidepressants.

Nature Neuropsychopharmacology
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Neurons That Restore Breathing After Spinal Cord Injury Identified

by Inside Precision Medicine

Neurons responsible for boosting the intensity of breathing when organs need more oxygen have been identified, unveiling a new target for treatments seeking to restore breathing after a spinal cord injury.

Inside Precision Medicine
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Artificial Intelligence and Gene Therapy Might Find Marriage in Brain Treatments

by Health and Science Editor

Emerging research hints at a powerful combination; AI and gene therapy poised to enhance brain treatments and offer solutions to some of the most challenging mental health disorders. Much like a recipe book for the mind, this approach adds a splash of engineering to physiological healing.

New Journal of Biomedical Contributions
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Organoids Used to Find New Alzheimer’s Disease Treatment Target

by Inside Precision Medicine

Researchers have developed organoid models to identify potential new treatment targets for Alzheimer's disease, enhancing the prospective efficacy of therapies.

Inside Precision Medicine
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Immune Attack on Smell Pathways May Signal Early Alzheimer’s

by Neuroscience News

A fading sense of smell may be one of the earliest warning signs of Alzheimer’s disease, with researchers discovering that microglia mistakenly remove nerve fibers crucial for processing odors, linking this phenomenon to the disease.

Neuroscience News
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MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder: A Randomized Controlled Trial

by ClinicalTrials.gov

This clinical trial evaluates the effectiveness of MDMA-assisted therapy among veterans suffering from PTSD and comorbid alcohol use disorder, aiming to improve treatment outcomes.

ClinicalTrials.gov
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Trustworthy AI Psychotherapy: Multi-Agent LLM Workflow for Counseling and Explainable Mental Disorder Diagnosis

by Mithat Can Ozgun et al.

This paper offers a multi-agent framework involving large language models (LLMs) aimed at improving therapy and mental disorder diagnosis, emphasizing trustworthiness and explainability.

Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial

by Florian Eichler et al.

A phase 1/2 trial of dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis, administered by bilateral intrathalamic, cisterna magna and intrathecal delivery found a dose-dependent biochemical correction of the disease.

Nature Medicine
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Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial

by Kari L. Kendra et al.

In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89%, supporting a new treatment option for this tumor type.

Nature Medicine
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Virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: a randomized controlled trial

by Ulrik N. Jeppesen et al.

A randomized controlled trial found no difference in paranoid ideations between virtual reality-based and gold-standard cognitive behavioral therapy for patients with schizophrenia spectrum disorders, in contrast to previous trials using wait-list or passive controls.

Nature Medicine
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Scientists May Have Found the Tiny DNA Switch That Made Us Human

by Science Daily

Scientists at UC San Diego have discovered a small but powerful section of DNA, called HAR123, that could help explain what makes the human brain so unique. Instead of being a gene, HAR123 acts like a switch controlling the development of neural processes.

Science Daily
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Microbial DNA in Blood Helps Distinguish Tumor Origins

by Inside Precision Medicine

Researchers show that fragments of microbial DNA circulating in blood can distinguish between primary liver cancer and colorectal cancer that has metastasized to the liver.

Inside Precision Medicine
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Implementing a Therapy for Complex Trauma in French-Speaking Settings

by ClinicalTrials.gov

This clinical trial investigates the implementation of a therapy designed for patients suffering from Complex Trauma in French-speaking environments, focusing on outcomes related to PTSD and related disorders.

ClinicalTrials.gov
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Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s disease

by Blaine E. Weiss et al.

This study investigates the alterations in calcium dynamics in reactive astrocytes associated with amyloid pathology in a mouse model of Alzheimer's disease, revealing potential mechanisms underlying neurovascular dysfunction.

Journal of Neuroscience
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A personal health large language model for sleep and fitness coaching

by Justin Khasentino et al.

A large language model designed for health monitoring provides personalized sleep and fitness predictions, insights and advice.

Nature Medicine
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Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas

by Neuroscience News

A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder. Using patient-derived pancreatic islets, researchers found reduced insulin secretion linked to elevated RORβ, a bipolar risk gene.

Neuroscience News
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