Naturalistic communication is an aim for neuroprostheses. Here the authors present a neuroprosthesis that restores the voice of a paralyzed person simultaneously with their speaking attempts, enabling naturalistic communication.
MDGA2 mutations, linked to autism spectrum disorder, result in dysregulated TrkB signaling, causing significant synaptic and behavioral disruptions. This research unveils crucial pathways affecting autism, posing future therapeutic potentials.
For the first time, researchers demonstrate in an animal model how heavy alcohol use leads to long-term behavioural issues by damaging brain circuits critical for decision-making, highlighting new avenues for intervention.
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
In studying the brain, we almost always take the neuron’s perspective. But we can gain new insights by reorienting our frame of reference to that of the messages flowing over brain networks.
New research reveals that fear of emotions may explain why individuals with PTSD symptoms often struggle to communicate with romantic partners. The study found that people with higher PTSD symptoms were more likely to fear strong emotions, which led to less constructive and more conflict-driven communication styles.
This research discusses how plasma metabolites have bidirectional causal relationships with bipolar disorder, potentially offering new avenues for understanding the disorder's biomolecular aspects.
This study dives into the brain's transformation from childhood to adolescence, unveiling the intricate re-organization correlated with cortical morphology and functional specialization. This research paves the way for targeted interventions in developmental disorders.
This study investigates heart rate variability (HRV) responses in both healthy individuals and patients with disorders of consciousness when exposed to personalized and non-personalized affective videos, exploring the impact of emotional stimuli on physiological responses.
This article proposes BOLDSimNet, a new framework that utilizes Multivariate Transfer Entropy to measure causal connectivity and network similarity in fMRI data across different cognitive states. The study reveals developmental variations in attentional fluctuations and network reconfiguration in children and adolescents.
This research article characterizes redox-active cysteines and their regulatory mechanisms for brain-selective kinases within the AMPK family.
Researchers have developed an at-home olfactory test that may help identify individuals at risk of Alzheimer's disease years before symptoms appear. The study found that cognitively impaired older adults scored lower on this test compared to cognitively normal adults.
In an iterative phase 2 trial, patients with metastatic, treatment-refractory, mismatch repair proficient gastrointestinal cancers had responses to neoantigen-reactive tumor-infiltrating lymphocytes but not bulk tumor-infiltrating lymphocytes, highlighting the potential for a refined immune cell therapy approach in this patient population.
The study examines how Sulforaphane has protective effects against synaptic alterations induced by valproic acid, providing insights into potential therapeutic approaches.
Research indicates that cognitive impairments related to depression can continue even after patients receive treatment with selective serotonin reuptake inhibitors (SSRIs). The study highlights the long-term impact of depression on cognitive functions, suggesting that individuals may face challenges in areas such as attention and memory despite being on medication.
This study aims to evaluate the effects of a smartphone app in conjunction with internet-based Cognitive Behavioral Therapy (ICBT) on depressive symptoms among adults currently on antidepressant medication.