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Brain connectivity and transcriptional changes induced by rTMS in first-episode major depressive disorder

Nature Translational Psychiatryby Muzhen Guan et al.

This study explores the effects of repetitive transcranial magnetic stimulation (rTMS) on brain connectivity and transcriptional alterations associated with major depressive disorder.

Decoding vital variables in predicting different phases of suicide among young adults with childhood sexual abuse: a machine learning approach

Nature Translational Psychiatryby Wenbang Niu et al.

This research employs a machine learning methodology to identify critical factors influencing suicidal ideation in young adults who experienced childhood sexual abuse.

Brain functional abnormality in drug naïve adolescents with borderline personality disorder during self- and other-reflection

Nature Translational Psychiatryby Pilar Salgado-Pineda et al.

The article investigates brain function abnormalities related to self- and other-reflection tasks in adolescents diagnosed with borderline personality disorder, who have not previously been treated.

Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

eLife Sciencesby Zahra Khodadadi et al.

This study presents a synaptic learning rule that utilizes local calcium signals and rewards to enhance dendritic processing, addressing the nonlinear feature binding problem in neural networks.

Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

eLifeby Jixing Li et al.

The research contrasts multi-talker speech comprehension across various temporal scales, comparing listeners with normal hearing and those with hearing impairments, shedding light on auditory processing in complex environments.

Cancer vaccine momentum builds, but US funding cuts raise concerns

Natureby Bec Crew

Vaccine scepticism could undermine important progress in cancer research.

Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial

Natureby Bryan R. Barksdale et al.

This article reports on a study investigating the effects of low-intensity transcranial focused ultrasound on the amygdala, assessing its efficacy and safety as a potential treatment modality for neuropsychiatric conditions.

A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge)

ClinicalTrials.govby ClinicalTrials.gov

This study assesses the efficacy of MM120 for individuals suffering from major depressive disorder in a Phase 3 trial.

Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories

eLife Sciencesby Rebecca RG et al.

The study reveals that the spatial periodicity observed in grid cell activity can be interpreted through a sequence coding mechanism, providing insights into how these cells contribute to spatial navigation.

Premature vision drives aberrant development of response properties in primary visual cortex

eLife Sciencesby Sophie V Griswold et al.

This study investigates the effects of premature visual inputs on the development of response properties in the primary visual cortex, with implications for understanding visual processing and developmental disorders.

Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms

eLifeby Yasuhiro Itoh et al.

The article focuses on the role of Bcl11b in the development of axons in subcerebral projection neurons, investigating both autonomous and non-autonomous mechanisms involved in this process.

Rhythmic Sampling and Competition of Target and Distractor in a Motion Detection Task

eLife Sciencesby Changhao Xiong et al.

This article explores the effects of rhythmic sampling and competition dynamics in the medial prefrontal cortex during motion detection tasks, contributing to our understanding of attentional processes.

Benchmark evaluation of DeepSeek large language models in clinical decision-making

Nature Medicineby Sarah Sandmann et al.

In an evaluation involving 125 standardized patient cases, open-source DeepSeek large language models are shown to perform at least on par with state-of-the-art proprietary large language models in diagnosis and treatment recommendation tasks.

Population analyses reveal heterogenous encoding in the medial prefrontal cortex during naturalistic foraging

eLife Sciencesby Ji Hoon Jeong et al.

This research uncovers diverse patterns of neural encoding in the medial prefrontal cortex, particularly in the context of naturalistic foraging behaviors.

Trends in Self-citation Rates in High-impact Neurology, Neuroscience, and Psychiatry Journals

eLifeby Matthew Rosenblatt et al.

The article analyzes self-citation trends across top journals in neurology, neuroscience, and psychiatry, providing valuable insights into publication practices and the impact of self-citing on academic metrics.

How AI is helping to boost cancer screening

Natureby Michael Eisenstein

Cancer blood tests and AI-powered scans look promising for quicker and more accurate detection of disease.