Researchers have developed lipid nanoparticles (LNPs) that cross the blood-brain barrier (BBB) and precisely target brain cells, a major step toward treating neurological diseases like Alzheimer’s. By attaching short peptides to LNPs, scientists achieved targeted mRNA delivery to neurons and endothelial cells, avoiding invasive procedures.
Researchers have developed lab-grown neurons that behave more like real brain networks, advancing the study of learning and memory. Using microfluidic devices, the neurons formed diverse and functional networks, resembling those seen in living nervous systems.
Researchers have created mini-brains to study how mitochondrial failure impacts brain cells, opening new possibilities for treating severe conditions like epilepsy. These brain organoids mimic real disease processes, allowing scientists to observe mitochondrial dysfunction and test potential treatments.
This article reports on a clinical trial investigating the use of prebiotics as an adjunct therapy for treating PTSD, examining the effects on symptoms and their potential mechanisms.
This original research article examines the dynamic changes and the potential prognostic value of glutathione S-transferase alpha in patients with mild cognitive impairment and Alzheimer's disease.
This study explores the neuroprotective properties of sialic-acid-binding immunoglobulin-like lectin-11 in a model of humanized transgenic mice, contributing to the understanding of its potential therapeutic applications.
This original research evaluates the synergistic neuroprotective effects of tauroursodeoxycholic acid, co-enzyme Q10, and creatine in in-vitro models pertinent to Parkinson's disease.
This study examines the involvement of frontal and posterior cortical regions in the nonspatial allocation of visual attention using functional neuroimaging techniques.
This article reviews behavioral analysis in rodent models related to both motor and non-motor impairments commonly observed in Parkinson's disease, aiming to elucidate the underlying mechanisms.
Neuroplastic changes in the brain may treat many types of mental illness. Read on to learn how psychoplastogens are transforming mental health treatment.
A study reveals how brain cell interactions influence aging, showing that rare cell types either accelerate or slow brain aging. Neural stem cells provide a rejuvenating effect on neighboring cells, while T cells drive aging through inflammation.
Recent findings indicate that mutated cilia may play a crucial role in the pathology of Amyotrophic Lateral Sclerosis (ALS), opening potential new avenues for therapeutic development.
This study examines the effects of behavioral activation on treatment outcomes related to depression among colon cancer patients.
This research article discusses the genetic factors influencing psychosis biotypes with a focus on ancestry-adjusted polygenic risks and unique genomic correlations.
The study investigates how signaling through the Oxytocin receptor in astrocytes influences anxiety-related behaviors, providing insights into potential therapeutic strategies for anxiety disorders.
Transcranial magnetic stimulation for alcohol use disorders is under investigation. Research to date suggests TMS could play a role in managing clinically-problematic alcohol use.