An atypical funding mechanism, truncated application timeline and opaque review process had generated concern over the quality of projects that would be selected for the Autism Data Science Initiative.
This systematic review and meta-analysis investigates the role of cortical 5-HT2A receptors in depression and suicidal behavior through both in vivo and post-mortem imaging studies.
Scientists have discovered that depression can be driven by abnormal sugar modifications on proteins in the brain, offering a new molecular pathway for understanding the disorder. Chronic stress was shown to reduce sialylation—a stabilizing sugar process—in the prefrontal cortex, impairing neural circuit stability and triggering depressive symptoms.
This study investigates how activity deprivation influences the Shank3/Homer1/mGluR5 signaling pathway, showing its role in facilitating synaptic upscaling.
Hailing from research labs in China, the aptly named 'NeuroWorm' is a microfiber designed to creep into the brain's echelons. Inspired by earthworms, this device monitors neural signals and promises advanced neuromonitoring—a veritable sliver of innovation.
This research explores the unique ultrastructural characteristics and plasticity of synapses created by adult-born and early-born interneurons in the mouse olfactory bulb.
This article reviews recent advancements in cognitive-behavioral therapy particularly focusing on its application in anxiety and related disorders.
This article discusses the factors contributing to suicide among older adults and effective strategies for prevention.
The article discusses the novel frontiers in critical care psychiatry and its integration within proactive and consultation-liaison psychiatry.
This article provides insights into identifying anxiety disorders in young children and approaches for effective treatment.
Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.
The study investigates the role of Pyk2 in hippocampal hyperactivity, Tau phosphorylation and synaptic loss associated with Alzheimer's disease-related alterations. Results show that genetic deletion of Pyk2 prevents neuronal hyperactivity and synaptic loss.
Researchers uncovered a key cellular regulator, PP2A-B55alpha, that controls both the cleanup of damaged mitochondria and the creation of new ones. In Parkinson’s disease models, reducing this regulator improved symptoms and mitochondrial health.
Research indicating the differential effects of M1 and M4 receptor activation by the muscarinic agonist ML-007 in psychosis models.
Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.
This article examines how lifestyle factors are integrated into clinical psychiatric practice and their relevance in patient care.