This prospective cohort study assesses the predictive power of subgenual cingulate connectivity metrics for anticipating responses to transcranial magnetic stimulation (TMS) in patients with depression.
This study investigates how the structure of tasks influences the geometric organization of neural representations within the lateral prefrontal cortex in humans.
This study investigates the availability of cannabinoid-1 receptors in patients with posttraumatic stress disorder using positron emission tomography.
A low-oxygen environment — similar to the thin air found at Mount Everest base camp — can protect the brain and restore movement in mice with a Parkinson’s-like disease, according to a new study led by scientists at Harvard Medical School, Massachusetts General Hospital, and the Broad Institute of MIT and Harvard.
New research from Bruce A. Yanker and colleagues, first author Liviu Aron, shows for the first time that lithium is naturally present in the brain, shields it from neurodegeneration, and maintains the normal function of all major brain cell types. The findings are based on a series of experiments in mice and on analyses of human brain tissue and blood samples from individuals in various stages of cognitive health.
This article identifies the role of histone demethylase PHF2 in the regulation of inflammatory genes related to Alzheimer's disease, proposing new therapeutic avenues.
Stress is a universal experience, but not all stress affects the brain in the same way. A new study in rats reveals that acute stress provokes anxiety-like behaviors, especially in males, while chronic stress is more strongly tied to depressive symptoms.
This article discusses findings indicating that symptoms associated with antidepressant withdrawal could be prevalent and more intense than previously reported, prompting a reevaluation of treatment protocols.
Longitudinal neuroimaging of participants with planned arm amputations shows that the cortical body map remains stable after amputation, with no evidence of hand or face reorganization, thus challenging long-standing theories of brain remapping after limb loss.
This article explores the use of machine learning to estimate the age gap in brain structures in patients with major depressive disorder, focusing on anhedonia as a symptom.
This research employs a nanophysiology approach to uncover the variability of calcium microdomains in zebrafish retinal bipolar cells, which is crucial for understanding synaptic signaling.
This article discusses a deep learning approach that connects mechanistic models to single-cell transcriptomics, revealing insights into transcriptional bursting due to DNA damage.
This systematic review evaluates the variability in behavioral and inflammatory responses to different stressors in rodent models of depression, examining how these responses differ by developmental stage and sex.
The research focuses on the role of circular RNAs in major depressive disorder, suggesting potential pathways for therapeutic innovation based on cellular identity modulation.
The article provides a weekly update highlighting notable news from scientific papers to funding rounds, focusing on strategies for drugging intrinsically disordered proteins and drug-resistant bacteria.
Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new therapeutic prospects for various brain diseases.