A first-of-its-kind clinical trial shows that ketamine treatment for severe, treatment-resistant depression is significantly more effective when paired with psychotherapy. Patients reported a 30% drop in depression symptoms, with reduced anxiety and suicidal thoughts lasting at least eight weeks.
A new study has examined brains affected by PTSD at the single-cell level, uncovering distinct genetic alterations that may drive the disorder. Researchers focused on the dorsolateral prefrontal cortex, analyzing individual cell nuclei to map communication differences across PTSD, major depression, and control brains.
Perceptual multistability offers insights into cognitive functions and potential dysfunctions in psychiatric disorders, providing new diagnostic perspectives.
The study explores how two distinct neural circuits linked to the lateral striatum mediate the acquisition of auditory discrimination, providing insights into the neural mechanisms underlying this cognitive process.
The article reviews advancements in Positron Emission Tomography (PET) technology and its applications in Alzheimer's disease research, highlighting the potential for improved diagnostic and therapeutic strategies.
A new theory suggests that the order of sleep phases—non-REM followed by REM—is essential for strengthening and organizing memories. In mice studies and computational models, researchers found that non-REM sleep reinforces new memories, while REM sleep prunes overlapping or irrelevant ones, keeping them distinct.
This study investigates the dynamic networks involved in emotional processing as seen through functional MRI, offering insights into the neural correlates of emotional experiences.
This research investigates the role of fatty acid amide hydrolase in patients with major depressive episodes, utilizing positron emission tomography with a specific radiotracer.
The research explores how inhibitory neural circuits in Drosophila generate rhythmic movements required for grooming behaviors, providing a model for understanding motor control.
Symmetry in neural learning rules improves spatial navigation representations in the brain, with implications for both human and animal cognitive science.
This work investigates the effects of psychedelics on the myelination process in female versus male APOE4 mice, highlighting the potential for sex-specific therapeutic approaches to myelin-related neuropsychiatric disorders.
This research examines how endocytic machinery is deployed to specific locations at nerve terminals regardless of active zone assembly processes, contributing to our understanding of synaptic function.
Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.
This study explores how inflammatory pain impacts the sleep architecture of mice, revealing that such conditions lead to variations in sleep patterns based on the light cycle.
The authors demonstrate that closed-loop electrical stimulation can prevent the interaction between pathological neural communication and the spread of the epileptic network, thereby preserving long-term memory in rodent models.
This research identifies the role of corticospinal-targeted spinal interneurons in mediating neuropathic pain responses following chronic CNS injury.