The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuations, with potential relevance for bipolar disorder.
By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that explains the retention of this intron segment in a translated mRNA.
Scientists have developed a targeted brain cell transplant that could transform treatment for Tay-Sachs and Sandhoff diseases. By depleting diseased microglia and replacing them with healthy donor precursor cells, researchers restored crucial enzyme function in the brain and dramatically extended lifespan in mice.
This paper discusses the development of a model called MDD-Net utilizing a mutual transformer approach for detecting depression through multimodal signals. It has been accepted for the 2025 IEEE International Conference on Systems, Man, and Cybernetics (SMC), Vienna, Austria.
A new imaging study reveals that young adults with a higher genetic risk for depression show diminished brain activity when processing rewards and punishments. Using data from nearly 900 healthy twins and siblings, researchers found altered activation in brain regions linked to attention and decision-making—well before any symptoms of depression appeared.
This review article explores how various environmental factors, termed the exposome, influence brain development and cognitive health.
Throwing light on the alpha rhythms that dance across our brain's visual areas, this study propagates excitement in neuroscience by exploring alpha-band traveling waves using EEG. This research is set to create ripples in understanding visual processing and cognitive functions, providing crucial insights for neuroimaging advancements.
New research on prairie voles shows that while oxytocin is not strictly necessary for friendship, it plays a vital role in quickly forming and maintaining strong social bonds. Voles lacking oxytocin receptors took up to a week to develop preferences for peers that normal voles formed in a day, and they often failed to prioritize known companions in group settings.
Researchers studying people with epilepsy have discovered that nerve cells in the medial temporal lobe coordinate their firing with slow brain waves to encode and retrieve memories. This synchronization, known as theta-phase locking, occurs at one to ten cycles per second and is active during both learning and recall.
A new study has found that sexual narcissism mediates the link between childhood trauma and compulsive sexual behavior. Researchers compared individuals with and without compulsive sexual behavior, measuring trauma history, sexual narcissism, and hypersexuality.
The study models the acoustic properties of low-intensity focused ultrasound, discussing potential applications and impacts on brain neuromodulation therapies.
The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer degeneration, but that layer IV is more pronounced in old age.
These data are “virtually mandatory” to advance neuroscience, says Ihunwo, a co-investigator of the Brain Research International Data Governance & Exchange (BRIDGE) initiative, which seeks to develop a global framework for sharing, using and protecting neuroscience data.
This article presents findings on how genomic data can be used to predict the risk of depression among older adults.
This article discusses new findings regarding dopamine's involvement in learning processes, challenging earlier assumptions and suggesting wider implications.
A new study reveals that the brain’s basal ganglia use two distinct neural 'languages' to control movement — one for learned skills and another for innate behaviors. Studying rats, researchers found that the dorsolateral striatum was essential for learned tasks but not for natural movements like walking or grooming.